South Padre Island is located at the bottom tip of Texas where the Rio Grande river meets the Gulf Of Mexico.
From Brownsville take TX-48 straight to the island. From Corpus Christi, head south on US-77. If you’re coming from the Rio Grande Valley, go east on US-83. A couple miles after US-77 & US-83 join together just past San Benito the hometown of Freddy Fender (He’s on the water tower), take the TX-100 exit to the island.
The nearest airport to fly is Brownsville International. It’s 20 miles from the island. Valley International in Harlingen is also an option 40 miles away. There are shuttle services available to the island from both.